TTM2-TAME Trial

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The latest from the Spiral blog . . .

Better Health Outcomes Together - The PANORAMIC Case Study with Lead Statistician Ly-Mee Yu

2023-03-13

‘One of the purposes behind the trial is discovering which antivirals are effective in keeping people away from the hospitals as much as they can and alleviating the burden on the healthcare system.'

The PANORAMIC trial is an adaptive platform trial aimed at finding early treatments for COVID-19 by evaluating new antiviral treatments in the community, reducing hospital admissions and easing the burden on the healthcare system.

The trial has recruited over 26,000 people across 65 sites using various recruitment strategies. Spiral’s Spinnaker platform has helped streamline the trial’s software requirements since October 2021. Recent results have shown that Molnupiravir does not reduce hospitalizations or deaths in higher-risk, vaccinated adults with COVID-19.

The trial will continue until a pre-specified probability of superiority or futility is met, and its success is attributed to collaboration within the medical community.

About the TTM2 Study

The TTM2 trial is a phase III, multi-centre, randomized, parallel-group, clinical trial in resuscitated cardiac arrest patients admitted to the intensive care unit to investigate whether targeted temperature management (TTM) to 33°C improves survival and neurological outcome at 6 months compared to a strategy of targeting normothermia and avoiding fever above 37.7°C. More information »

About the TAME Study

The TAME trial is a phase III, multi-centre, randomised, parallel-group, clinical trial in resuscitated cardiac arrest patients admitted to the intensive care unit to determine whether targeted therapeutic mild hypercapnia (TTMH) improves neurological outcome at 6 months compared to standard care (targeted normocapnia) (TN). More information »

About the software

Spinnaker is a tailored, web based, software and database solution for managing your multi-centre clinical study including the recording of patient data, recording and alerting of events, inventory management and reporting on data collected during the course of your study. Spinnaker is user friendly, adaptable and can be delivered quickly. You can read more on the Spinnaker website or contact Audrey on spinnaker@spiral.co.nz.

You can get to know us a little better through our blog and social media pages accessed via the logout screen of this trial.